DNA photolyase repairs the trans-syn cyclobutane thymine dimer
- 1 July 1993
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 32 (28) , 7065-7068
- https://doi.org/10.1021/bi00079a001
Abstract
DNA photolyases catalyze the splitting of the cyclobutane ring joining the two dihydropyrimidines of a pyrimidine dimer by a photoinduced electron-transfer reaction. Previous studies concluded that photolyase repairs only the cis-syn form of the eight stereoisomers of the cyclobutane pyrimidine dimer (Pyr[ ]Pyr). In this study we found that Escherichia coli photolyase binds to the trans-syn-I isomer of T[ ]T with about 10(4)-fold lower affinity than the cis-syn isomer but it repairs it relatively efficiently.Keywords
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