Karyotypic Evolution in a Patient with a Preleukemic State of Adult T-cell Leukemia (Pre-ATL) progressing to Overt ATL
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 6 (2) , 177-181
- https://doi.org/10.3109/10428199209064892
Abstract
Karyotypic evolution in a 56-year-old male with a preleukemic state of adult T-cell leukemia (pre-ATL) that progressed to overt ATL is described. The patient was born in the Kagoshima district, an endemic ATL area in Japan. A clone with inv(14)(q11q32) which was not detected in a pre-ATL state appeared during the early phase of overt ATL. These findings suggest that inv(14)(q11q32) may have played an important role in leukemogenesis in the present case. Based on our cytogenetic data obtained from both the pre-ATL and overt ATL phases, a model of the leukemogenic process of ATL is proposed.Keywords
This publication has 16 references indexed in Scilit:
- Specific abnormalities of chromosome 14 in patients with acute type of adult T‐cell leukemia/lymphomaInternational Journal of Cancer, 1987
- Significance of chromosome 14 anomaly at band 14Q11 in Japanese patients with adult T-cell leukemiaCancer, 1986
- Human T-lymphotropic retrovirusesNature, 1985
- Abnormalities of chromosome 14 at band 14q11 in Japanese patients with adult T-cell leukemiaCancer Genetics and Cytogenetics, 1985
- Molecular basis of human B cell neoplasiaBlood, 1985
- Methylation of human T-cell leukemia virus proviral DNA and viral RNA expression in short- and long-term cultures of infected cellsVirology, 1984
- Cytogenetic studies on patients with chronic T cell leukemia/lymphomaBlood, 1984
- Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.Proceedings of the National Academy of Sciences, 1981
- Chromosomes in Acute Non‐lymphocytic LeukaemiaBritish Journal of Haematology, 1978
- ISCN 1978Cytogenetic and Genome Research, 1978