The response of the renal and femoral vascular beds to coronary embolization in the dog

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Abstract
The renal, femoral, and systemic vascular responses to coronary embolization with mercury were studied in anaesthetized dogs. Systemic and femoral vascular resistance increased after embolization while the renal vascular bed exhibited marked vasodilatation, manifested in many instances by an actual increase in the level of renal blood flow. The renal vasodilator response started promptly following embolization (mean decrease in renal vascular resistance 28 ± 4% [SEM] at 2 min after embolization). Renal vascular resistance was still significantly decreased 30 min following embolization and it remained decreased for at least 90 min in some instances. The ability of the kidney to respond to an exogenous vasoconstrictive stimulus (1-noradrenaline) was not impaired after coronary embolization. It is concluded that while the femoral vascular bed participates in the systemic vasoconstrictive response to coronary embolization, the renal circulation is under the influence of still undefined vasodilator stimuli of early onset and sustained action.

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