Protein synthesis and the temporal control of genetic transcription during slime mold development.

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Abstract
During morphogenesis in Dictyostelium discoideum strain FR-17 there was a 4-hour period of RNA synthesis, delineated by actinomycln sensitivity, which was required for the appearance of the enzyme UDP-galactose polysaccharide transferase. Interference with protein synthesis during this transcription disrupted the transcriptive process but did not affect the transferase-specific RNA previously fabricated. The cells appeared to compensate for the disruption of initiating a 2nd round of transcription after the resumption of protein synthesis. By these means the period of transferase-specific RNA synthesis was extended considerably beyond its normally prescribed time limits.