Structure and conformation of fourteen antibiotics of the quinoxaline group determined by 1H NMR.
- 1 January 1982
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 35 (1) , 62-66
- https://doi.org/10.7164/antibiotics.35.62
Abstract
NMR was employed to characterize 14 new antibiotics belonging to the quinoxaline group, produced by feeding aromatic acids to Streptomyces echinatus. Twelve of the antibiotics are the expected substituted quinomycins and adopt conformations very similar to that of echinomycin. This is discussed in relation to their different DNA-binding characteristics. The other 2 antibiotics are triostins, supporting the proposal that triostins serve as biosynthetic precursors of the quinomycins.This publication has 1 reference indexed in Scilit:
- The conformation of echinomycin in solutionJournal of the American Chemical Society, 1978