Oxidative Metabolism
- 1 December 2000
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 924 (1) , 164-169
- https://doi.org/10.1111/j.1749-6632.2000.tb05575.x
Abstract
There is a large body of evidence showing both metabolic defects and oxidative damage in Alzheimer's disease. Studies of cybrid cell lines show reduced cytochrome oxidase. There is also substantial evidence for a defect in alpha-ketoglutarate dehydrogenase. It is therefore possible that therapeutic strategies to improve brain metabolism or ameliorate oxidative damage might be useful in treating Alzheimer's disease.Keywords
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