Robust Mixed 10/12 Helices Promoted by “Alternating Chirality” in a New Family of C-Linked Carbo-β-peptides
- 17 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (45) , 13670-13671
- https://doi.org/10.1021/ja035752i
Abstract
The C-linked carbo-beta-peptides, oligomers of a new class of C-linked carbo-beta3-amino acids, have been shown to generate mixed 12/10 and 10/12 helices. The design involves use of "alternating chirality" of the epimeric (at the amine center) monomers to control the stability of these helices. The observation of stable 12/10 helix in a tripeptide and 10/12 helix in a tetrapeptide is unprecedented.Keywords
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