CELLS MEDIATING GRAFT REJECTION IN THE MOUSE
- 1 April 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 33 (4) , 407-410
- https://doi.org/10.1097/00007890-198204000-00013
Abstract
Skin graft rejection in ATXBM CBA mice reconstituted with naive (nonsensitized) cells was shown to be mediated predominantly by Ly-1+2- effector T cells. Thus, after the treatment of the inoculum with the monoclonal anti-Ly-1.1 antibody and complement, C57BL/6 skin grafts survived indefinitely, whereas Ly-2 antibody depletion merely delayed the onset of rejection. This showed that a Ly-1+2- precursor cell rather than a Ly-1+2+ cell was the progenitor of the Ly-1+2- graft rejection effector cell. Nevertheless, another T cell subset augmented the rejection of skin grafts and it was concluded that Ly-1,2,3+ cells also provided a pool of precursor cells. Thus, it appeared that both Ly-1+ and Ly-1,2,3+ cells can function as precursor cells for the effector cells, which, as shown previously, have the Ly-1+ phenotype.This publication has 14 references indexed in Scilit:
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