Origins of CD4+ effector and central memory T cells
- 18 May 2011
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 12 (6) , 467-471
- https://doi.org/10.1038/ni.2038
Abstract
Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.Keywords
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