The Free Radical Scavenger, α-Lipoic Acid, Protects Against Cerebral Ischemia-Reperfusion Injury in Gerbils
- 1 January 1995
- journal article
- Published by Taylor & Francis in Free Radical Research
- Vol. 23 (4) , 365-370
- https://doi.org/10.3109/10715769509065257
Abstract
Alpha-Lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion. Adult gerbils were treated for 7 days with two intraperitoneal injections per day of alpha-lipoic acid (20 mg/kg), vehicle or saline and on the 7th day the animals were subjected to 5 min of forebrain ischemia. Ischemic injury was assessed by monitoring the increases in locomotor activity and from the extent of damage to the CA1 hippocampal pyramidal cell layer after 5 days of recovery. By both criteria, alpha-lipoic acid was neuroprotective against ischemia/reperfusion evoked cerebral injury.Keywords
This publication has 26 references indexed in Scilit:
- Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysisNeuroscience Letters, 1992
- Protective effects of human recombinant superoxide dismutase on transient ischemic injury of CA1 neurons in gerbils.Stroke, 1992
- The Free Radical Trapping Agent N-Tert.-Butyl-α-Phenylnitrone (PBN) Attenuates Cerebral Ischaemic Injury in GerbilsFree Radical Research Communications, 1991
- Free radicals in central nervous system ischemia.Stroke, 1990
- The Molecular Basis of Brain Injury and Brain Edema: The Role of Oxygen Free RadicalsNeurosurgery, 1990
- Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbilBrain Research Bulletin, 1989
- Lipid peroxidation in focal cerebral ischemiaJournal of Neurosurgery, 1989
- Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidationFree Radical Biology & Medicine, 1989
- Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
- The Standard Redox Potential of Cysteine-Cystine from the Thiol-Disulphide Exchange Reaction with Glutathione and Lipoic AcidEuropean Journal of Biochemistry, 1967