TOXIC PSYCHOSIS DUE TO OVERDOSAGE WITH PROPHENPYRIDAMINE (TRIMETON®)

12 August 1950

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 143 (15) , 1334-1335
https://doi.org/10.1001/jama.1950.82910500014007c

Abstract

In view of the extensive use of the antihistaminic drugs, instances of toxicity or unusual responses should regularly be brought to the attention of the members of the medical profession. Reports of serious side actions and even fatality¹have been noted. The former have followed either usual or excessive dosages. Toxic reactions are variable and may occur with a small dose in a person at one time but may fail to occur in the same person receiving larger doses at another time.²Toxic psychosis due to overdosage with prophenpyridamine (trimeton®) has occurred in 2 cases with recovery. No reports of poisoning, unusual toxic effects or fatalities have been found following the use of prophenpyridamine (1-phenyl-1-[2-pyridyl]-3-dimethylaminopropane). It is generally considered to be an antihistaminic of high activity and relatively low toxicity. Aside from its antihistaminic action it possesses some antispasmodic activity as measured by its ability to relax isolated

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