Type II‘β‐bend conformation of tert.‐butyloxycarbonyl‐L‐amino‐succinyl‐L‐alanyl‐glycine methyl ester in the solid state
- 1 December 1984
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 24 (6) , 588-596
- https://doi.org/10.1111/j.1399-3011.1984.tb03164.x
Abstract
Boc-L-Asu-L-Ala-Gly-OMe crystallizes in the monoclinic space group P21 with cell dimensions a = 14.315(3) Å, b = 9.280(2) Å, c = 14.358(3) Å, β= 103.63 (1) d̀, V= 1853.4(9) Å3, with two molecules in the asymmetric unit. The conformation of the two molecules is characterized by a type II' β-bend, similar to that predicted earlier by potential energy calculations, stabilized by an intramolecular hydrogen bond. I.r. and 1H-n.m.r. data show that the folded conformation is also stable in chloroform solution.Keywords
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