Generation of Novel Rapamycin Structures by Microbial Manipulations.
- 1 January 1995
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 48 (7) , 657-666
- https://doi.org/10.7164/antibiotics.48.657
Abstract
A new rapamycin producing culture was isolated and designated as Actinoplanes sp. N902-109. The addition of a cytochrome P-450 inhibitor and precursor feeding using this culture, and biotransformation approaches generated new rapamycin analogs with modifications at C-4, C-9, C-16, C-27, C-28 and/or C-39. The immunosuppressive activity of the resulting analogs was established in the mixed lymphocyte reaction assay.Keywords
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