A synthesis of 2-deoxy-2-{18F}fluoro-D-glucose using accelerator-produced 18F-fluoride ion generated in a water target
- 1 December 1984
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 62 (12) , 2709-2711
- https://doi.org/10.1139/v84-461
Abstract
A synthesis of 2-deoxy-2-{18F}fluoro-D-glucose (2-{18F}DFG) [used in the measurement of regional cerebral glucose metabolism] from 1,2-anhydro-3,4:5,6-di-O-isopropylidene-1-C-nitro-D-mannitol was developed. The procedure employed 18F produced by the 16O(3He,p)18F reaction using a water target. The label was introduced using KH{18F}F2 dried by microwave heating; the 18F-labeled derivative, upon treatment with 80% trifluoroacetic acid, afforded 2-{18F}DFG in a radiochemical yield of 10%. The total time of the synthesis was less than 110 min.This publication has 8 references indexed in Scilit:
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