Secretion of Human Prolactin In Vitro

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Abstract
Summary Cells from two human pituitary tumors were grown in capillary culture units and prolactin production was measured. A single unit could produce 3 mg of prolactin over a 4-month period. The cultured cells responded to TRH exposure by increasing their rate of prolactin secretion. Cultivation of cells in capillary units could be the method of choice for reducing the shortage of human hormones. The authors appreciate the suggestions of Drs. Pie-tro M. Gullino, Andreas Chrambach, and Walter Lov-enberg. We are indebted to Drs. Walter Lockhardt, Frank Neelon, and Tom Huff for obtaining the pituitary tissues. We also thank Mr. Norman Beaudry and Ms. Sharon McAvinue for technical assistance.

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