Comparison of two tests useful in situations where treatment is expected to increase variability relative to controls
- 15 December 1993
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 12 (23) , 2233-2243
- https://doi.org/10.1002/sim.4780122308
Abstract
The type I error and power characteristics of the modified t test were compared with those of the generalized t test. Results suggested that, in contrast to the generalized t test, the modified t test can be seriously non‐robust to departures from population normality, with such departures often producing anti‐conservative results. Neither test held an absolute power advantage over the other when responses were from normal distributions, but the modified t test was generally more powerful for these conditions. In comparison with the pooled samples t test, both tests were usually much more efficient when treatment caused increases both in mean response and between‐subject variance, and suffered only small disadvantages when between‐subject variance was unchanged by treatment. Given these results and other considerations, recommendations for use of these recently devised tests are given.Keywords
This publication has 7 references indexed in Scilit:
- New critical values for the generalized t and generalized rank-sum proceduresCommunications in Statistics - Simulation and Computation, 1991
- Application of new two-sample tests to data from a randomized placebo-controlled heart-failure trialStatistics in Medicine, 1990
- Modifying the t and ANOVA F Tests When Treatment Is Expected to Increase Variability Relative to ControlsBiometrics, 1990
- Comparing Two Samples: Extensions of the t, Rank-Sum, and Log-Rank TestsJournal of the American Statistical Association, 1988
- Two-Sample Rank Tests for Detecting Changes That Occur in a Small Proportion of the Treated PopulationBiometrics, 1987
- Teratogenic effect of calcium edetate (CaEDTA) in rats and the protective effect of zincToxicology and Applied Pharmacology, 1986