The comparative efficacy of buspirone and diazepam in the treatment of anxiety

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Abstract
Adult psychoneurotic outpatients (56) with a primary diagnosis of anxiety neurosis were randomly assigned to receive buspirone (18), diazepam (20) or placebo (18) over 4 wk. A battery of tests administered weekly indicated that buspirone, a new agent not chemically related to any currently marketed drugs, was as effective an antianxiety agent as diazepam and produced no more and perhaps fewer side effects. Buspirone showed excellent antidepressant effects as well. If buspirone does not result in tolerance and addiction, it would be more advantageous than the benzodiazepines in the treatment of anxiety.

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