Leptin-Replacement Therapy for Lipodystrophy
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Open Access
- 21 February 2002
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 346 (8) , 570-578
- https://doi.org/10.1056/nejmoa012437
Abstract
The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic steatosis, we assessed whether leptin replacement would ameliorate this condition.Keywords
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