Circulating Antigen-Antibody Complex Associated With Epstein-Barr Virus in Recurrent Burkitt's Lymphoma2
- 1 October 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (4) , 1319-1321
- https://doi.org/10.1093/jnci/51.4.1319
Abstract
Four years after initial diagnosis and treatment, the sera from a patient with recurrent Burkitt's lymphoma showed a sudden decrease of antibodies to Epstein-Barr virus (EBV)-associated membrane antigens (MA). This decrease occurred several months before the recurrent tumor became cllnlcally apparent. Simultaneously, the sera developed a high anticomplementary activity (ACA). The ACA was associated with the globulin fraction as demonstrated by ammonium sulfate precipitation. Low pH treatment of the globulin of one serum and Amicon filtration restored anti-MA reactivity to the fraction retained above the filter (molecules >105 Daltons). These data seem to indicate that MA-antibody complexes were present in the patient's serum.Keywords
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