Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: A double‐blind clinical trial

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Abstract
A double‐blind clinical trial of tranexamic acid was carried out on 39 patients with fresh subarachnoid hemorrhage from a ruptured aneurysm. Twenty patients received tranexamic acid, 6 gm daily for 14 to 21 days, while 19 patients received conventional therapy of bedrest and dexamethasone when cerebral edema developed, plus isotonic saline. Rebleeding and mortality were reduced by one‐fourth and one‐fifth, respectively (p < 0.001). No side‐effects were observed. Tranexamic acid is valuable in the treatment of subarachnoid hemorrhage caused by ruptured intracranial aneurysms.