Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines
- 30 April 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (5) , 605-611
- https://doi.org/10.1021/jm00227a006
Abstract
A quantitative structure-activity relationship (QSAR) was formulated for antitumor quinazolines causing 50% inhibition of liver dihydrofolate reductase. The QSAR for the quinazolines is compared with QSAR for triazine and pyrimidine inhibitors. The 3 QSAR suggest new possibilities for the design of inhibitors of mammalian dihydrofolate reductase.This publication has 0 references indexed in Scilit: