Microcytosis Associated with Sickle Cell Anemia
Open Access
- 1 July 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 72 (1) , 63-64
- https://doi.org/10.1093/ajcp/72.1.63
Abstract
Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic- disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with “relative microcytosis,” presumably a consequence of reduced hemoglobin production.Keywords
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