Inhibition of Leukocyte Phagocytic Activity by Hypergammaglobulinemic Multiple Myeloma Plasma.
- 1 November 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 105 (2) , 404-407
- https://doi.org/10.3181/00379727-105-26124
Abstract
Phagocytosis of saccharated iron by leukocytes (WBC) in vitro is virtually completely inhibited when the cells are suspended in hypergammaglobulinemic multiple myeloma (M.M.) plasma. Depressed phagocytic activity is directly attributable to gamma globulin fraction in M.M. plasma and not to a cell defect. Plasma from M.M. patients with hypergammaglobulinemia not due to M.M. does not inhibit WBC phagocytic activity. Inhibited phagocytosis appears not to be solely a function of total gamma globulin level and not to be due to a deficiency of normal serum gamma globulin.Keywords
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