DEVELOPMENT OF PLURIPOTENT HEMATOPOIETIC PROGENITOR CELLS IN THE HUMAN-FETUS
- 1 January 1983
- journal article
- research article
- Vol. 62 (1) , 118-123
Abstract
Pluripotent hematopoietic progenitor cells (CFU-GEMM), myeloid progenitor cells (CFU-GM), and erythroid progenitors (BFU-E) were studied in midtrimester human fetuses using the mixed colony assay. All 3 progenitor cell populations were detected at high levels in the fetal liver from 12-23 wk of gestation. Stem cells were 1st observed in the bone marrow at 15-16 wk of gestation, although bone marrow cultures from earlier fetuses showed heavy growths of stromal cells. Spleen cultures 1st showed growth of stem cells at 18-19 wk, but fetal thymus showed no hematopoietic activity. Peripheral blood from 4 fetuses aged 13, 18, 20 and 21 wk showed very high levels of all 3 progenitor cells. Hematopoietic development in the human fetus parallels that of the mouse. The observation that stromal cell development in the bone marrow precedes the appearance of hematopoietic progenitor cells suggests that they may be closely involved in stem cell growth.This publication has 3 references indexed in Scilit:
- THE ONTOGENY OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE POSITIVE CELLS IN THE HUMAN-FETUS1983
- IDENTIFICATION OF MEGAKARYOCYTES, MACROPHAGES, AND EOSINOPHILS IN COLONIES OF HUMAN-BONE MARROW CONTAINING NEUTROPHILIC GRANULOCYTES AND ERYTHROBLASTS1979
- HBF AND HBA PRODUCTION IN ERYTHROID CULTURES FROM HUMAN FETUSES AND NEONATES1979