Discovery of Novel Catalysts for Allylic Alkylation with a Visual Colorimetric Assay
- 26 October 1999
- journal article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 38 (21) , 3163-3165
- https://doi.org/10.1002/(sici)1521-3773(19991102)38:21<3163::aid-anie3163>3.0.co;2-#
Abstract
The first non-phosphane iridium catalyst, made from [{IrCl(cod)}(2)] and iPr-pybox (shown schematically; cod=1,5-cyclooctadiene), for allylic alkylation in neutral medium was discovered by a simple, rapid, and inexpensive screening assay. The red coloration upon treatment of the reaction mixtures with Fast Red (see the 96-well plate) indicates the presence of 1-naphthol and thus the occurrence of allylic alkylation.Keywords
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