THE EFFECT OF CERTAIN HORMONE-LIKE SUBSTANCES ON THE ISOLATED HEART OF THE SKATE

1 January 1932

journal article
Published by Canadian Science Publishing in Contributions to Canadian Biology and Fisheries

Vol. 7 (1) , 31-43
https://doi.org/10.1139/f32-004

Abstract

The excised hearts of spinal skates (Raja spp.) were employed, using a modified Straub method with Smith's perfusion fluid. Adrenaline, when added to the perfusion fluid, produced both acceleration and augmentation of the heart beats, but after atropine adrenaline had scarcely any effect. Acetyl choline diminished the rate and decreased the amplitude of the heart beat but on addition of atropine the beat returned to normal. Histamine produced augmentation and a slight acceleration of the heart beat. It was concluded that the skate heart reacts to this substance in much the same way as does the mammalian heart but in the case of the skate there is a rather poorly developed sympathetic innervation.

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