SVMHC: a server for prediction of MHC-binding peptides
Open Access
- 1 July 2006
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 34 (Web Server) , W194-W197
- https://doi.org/10.1093/nar/gkl284
Abstract
Identification of MHC-binding peptides is a prerequisite in rational design of T-cell based peptide vaccines. During the past decade a number of computational approaches have been introduced for the prediction of MHC-binding peptides, efficiently reducing the number of candidate binders that need to be experimentally verified. Here the SVMHC server for prediction of both MHC class I and class II binding peptides is presented. SVMHC offers fast analysis of a wide range of alleles and prediction results are given in several comprehensive formats. The server can be used to find the most likely binders in a protein sequence and to investigate the effects of single nucleotide polymorphisms in terms of MHC-peptide binding. The SVMHC server is accessible at http://www-bs.informatik.uni-tuebingen.de/SVMHC/.Keywords
This publication has 31 references indexed in Scilit:
- NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteinsNucleic Acids Research, 2004
- Modeling the structure of bound peptide ligands to major histocompatibility complexProtein Science, 2004
- Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approachBioinformatics, 2004
- Reliable prediction of T‐cell epitopes using neural networks with novel sequence representationsProtein Science, 2003
- The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003Nucleic Acids Research, 2003
- Structure‐based prediction of binding peptides to MHC class I molecules: Application to a broad range of MHC allelesProtein Science, 2000
- Two complementary methods for predicting peptides binding major histocompatibility complex moleculesJournal of Molecular Biology, 1997
- Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA moleculesHuman Immunology, 1996
- Molecular Dynamics Simulation of MHC-Peptide Complexes as a Tool for Predicting Potential T Cell EpitopesBiochemistry, 1994
- Exact prediction of a natural T cell epitopeEuropean Journal of Immunology, 1991