No increased chromosome breakage in three Bloom's syndrome heterozygotes.
Open Access
- 1 June 1979
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 16 (3) , 219-222
- https://doi.org/10.1136/jmg.16.3.219
Abstract
The frequency of chromosome aberrations in the lymphocytes of three established heterozygotes for the Bloom's syndrome gene (ages 67, 57, 46) was compared to that in controls (ages 68, 67, 61, 46, 34). The main part of the study was done on coded slides. No difference was found between the heterozygotes and the control group, except for one control (aged 46) who had a significantly higher number of chromosome aberrations than the others.This publication has 18 references indexed in Scilit:
- Mitotic chiasmata and other quadriradials in mitomycin C-treated Bloom's syndrome lymphocytesChromosoma, 1978
- Bloom's syndrome in two Dutch familiesClinical Genetics, 1977
- Chromatid exchanges in ataxia telangiectasia, Bloom syndrome, Werner syndrome, and xeroderrna pigmentosumAnnals of Human Genetics, 1976
- Distribution of spontaneous chromosome breaks in human chromosomesHuman Genetics, 1976
- Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndromeChromosoma, 1976
- Cytogenetic investigations in a new case of Bloom's syndromeHuman Genetics, 1976
- Cytological demonstration of mitotic crossing-over in manCytogenetic and Genome Research, 1976
- Cytogenetic studies in control men and womenCytogenetic and Genome Research, 1973
- Fanconi's Anaemia in the Genetics of NeoplasiaNature, 1971
- Chromosome Abnormalities in Lymphocytes from Normal Human SubjectsCytogenetic and Genome Research, 1967