IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS
Open Access
- 1 January 1971
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 133 (1) , 39-52
- https://doi.org/10.1084/jem.133.1.39
Abstract
A partially purified blood group-like substance obtained from milk showed I activity with 2 of 21 anti-I sera. With these antisera, certain human ovarian cyst substances considered to be precursors of the A, B, H, Lea, and Leb substances also showed I activity comparable to the milk material. Strong I activity could be produced by one-stage periodate oxidation and Smith degradation of human ovarian cyst A and B substances, or of hog mucin A + H substance, or by mild acid hydrolysis of human saliva or ovarian cyst blood group B substance. The two sera indicate that I specificity appears at intermediate stages in the biosynthesis of the A, B, H, Lea, and Lea substances. Anti-I sera differ strikingly in their specificities, indicating substantial heterogeneity of the I determinants.Keywords
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