IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
Top Cited Papers
Open Access
- 9 July 2009
- journal article
- Published by American Society of Hematology in Blood
- Vol. 114 (2) , 346-356
- https://doi.org/10.1182/blood-2008-12-191296
Abstract
Murine models indicate that interleukin-10 (IL-10) can suppress viral clearance, and interventional blockade of IL-10 activity has been proposed to eKeywords
This publication has 65 references indexed in Scilit:
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionThe Journal of Experimental Medicine, 2008
- IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infectionThe Journal of Experimental Medicine, 2008
- HIV-1 gp120 Mannoses Induce Immunosuppressive Responses from Dendritic CellsPLoS Pathogens, 2007
- Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+T Cells Associated with Reversible Immune DysfunctionJournal of Virology, 2007
- Interleukin-10 determines viral clearance or persistence in vivoNature Medicine, 2006
- Resolution of a chronic viral infection after interleukin-10 receptor blockadeThe Journal of Experimental Medicine, 2006
- PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionThe Journal of Experimental Medicine, 2006
- Elevations in IL-10, TNF-α, and IFN-γfrom the Earliest Point of HIV Type 1 InfectionAIDS Research and Human Retroviruses, 2006
- Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10Proceedings of the National Academy of Sciences, 2000
- Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.Journal of Clinical Investigation, 1996