Plasmin cleaves Aβ42 in vitro and prevents its aggregation into β-pleated sheet structures
- 1 September 2001
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 12 (13) , 2967-2970
- https://doi.org/10.1097/00001756-200109170-00042
Abstract
The formation, aggregation and deposition of amyloid beta peptide (Abeta) is implicated in the aetiology of Alzheimer's disease. Impairment of proteolytic degradation of Abeta may be a key factor in the progression of the disease. We have used RP-HPLC and thioflavin T fluorescence to demonstrate that Abeta42 is rapidly cleaved by the protease plasmin and that cleavage prevented the aggregation of Abeta42, and its cleavage products, into beta-pleated sheet structures. Plasmin may fulfil a similar role in vivo.Keywords
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