Losses of Bacteriostats from Injections in Rubber-Closed Containers

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Abstract
The losses of bacteriostats from rubber-closed multidose containers of injections are confirmed, and the mechanism of these losses by absorption, diffusion and volatilisation is discussed. The present B.P. methods of pretreating rubber closures are inadequate, and methods for their more satisfactory equilibration with various bacteriostatic solutions are given. From measurements of the partition ratios of the B.P. bacteriostats and of benzyl alcohol between rubber and water, phenol and benzyl alcohol appear to be the most stable and promising and phenylmercuric nitrate the least stable. The value of using closures equilibrated for phenol and benzyl alcohol is demonstrated and methods for preventing the diffusion losses are discussed.

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