Minimum Alveolar Concentrations of Methoxyflurane, Halothane, Ether and Cyclopropane in Man

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Abstract
The minimum anesthetic concentration (MAC) required in man to prevent a muscular response to a skin incision in 50% of the subjects was determined for cyclopropane, halothane, di-ethylether and methoxyflurane in man. These were (volumes% at one atmosphere) cyclopropane 9.2, halothane 0.765, diethyl ether 1.92 and methoxyflurane 0.16. These values, along with the previously determined MAC''S for fluroxene (3.4%) and nitrous oxide (101%), represent equipotent doses of these agents and provide a useful standard when comparing the circulatory, respiratory or other physiologic effects of one anesthetic with those of another. MAC as a measure of anesthetic potency correlates better with lipid solubility than with any other physical constant. This correlation should be considered when the primary site of anesthetic action within the brain is sought.

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