Plant Antitumor Agents, 19. Novel Triterpenes from Maprounea africana
- 1 July 1983
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 46 (4) , 537-543
- https://doi.org/10.1021/np50028a019
Abstract
Four new pentacylic triterpenes were isolated from M. africana. These triterpenes are members of the previously unknown urs-12-en-29-oic acid series. The structures of these compounds were deduced from spectral and chemical evidence. The parent compound, maprounic acid, was identified as 3.beta.-hydroxyurs-12-en-29-oic acid. The remaining 3 triterpenes were identified as maprounic acid 3-.pi.-hydroxybenzoate, 7.beta.-hydroxymaprounic acid 3-p-hydroxybenzoate and 2.alpha.-hydroxymaprounic acid 2,3-bis-p-hydroxybenzoate. Of the 4- triterpenes, only the 7.beta.-hydroxy derivative exhibited in vivo P-388 [mouse lymphocytic leukemia] activity.This publication has 0 references indexed in Scilit: