In Situ Hybridization Detection of Human Herpesvirus 6 in Brain Tissue From Fatal Encephalitis
- 1 February 2000
- journal article
- case report
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 105 (2) , 431-433
- https://doi.org/10.1542/peds.105.2.431
Abstract
A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.Keywords
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