Refractory Hypotension in Man — Is This Irreversible Shock?

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Abstract
AFTER a decade of reports on the phenomena of Shock in the dog, there is a need to return to studies in man. The histochemical sequences of tissue death in dog and man are doubtless similar. By contrast, the elaborately integrated circulatory responses of the whole organism, postural reflexes, dietary habits and bacteriology of the two species are strikingly different. The controlled experimental study of shock in the dog in the laboratory is quite simple to undertake, but sequential observations in the seriously injured human subject are notoriously difficult to make and require an elaborate organization if they are to . . .