Comparative Antigenicity of Native and "Desialized"Orosomucoid in Rabbits.
- 1 November 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 111 (2) , 353-356
- https://doi.org/10.3181/00379727-111-27790
Abstract
Removal of sialic acid from the human serum glycoprotein orosomucoid (OM), by influenza virus neuraminidase, results in significantly increased antigenicity of this glycoprotein in the rabbit. The antigens were injected intramuscularly in two groups of 9 rabbits, using Freund''s adjuvant. Native and desialized OM react in a qualitatively and quantitatively similar manner with antibodies to the normal or desialized antigen. Thus the sialic acid, although a terminal sugar, is not an important antigenic determinant group.Keywords
This publication has 6 references indexed in Scilit:
- Isolation and characterization of an acidic α2-glycoproteinBiochimica et Biophysica Acta, 1961
- Studies on the neuraminidase of influenza virusArchives of Biochemistry and Biophysics, 1961
- Étude des séromucoïdes perchlorosolubles du sérum sanguin humain en électrophorèse de zonesClinica Chimica Acta; International Journal of Clinical Chemistry, 1960
- The Thiobarbituric Acid Assay of Sialic AcidsJournal of Biological Chemistry, 1959
- IMMUNOCHEMICAL DETERMINATION OF OROSOMUCOID1955
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951