Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus
Open Access
- 1 February 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (2) , 810-812
- https://doi.org/10.1128/aac.50.2.810-812.2006
Abstract
Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.Keywords
This publication has 19 references indexed in Scilit:
- NCCLS perspectives in changing susceptibility breakpoints for antimicrobial drugsInternational Journal of Antimicrobial Agents, 2003
- A novel inhibitor of multidrug efflux pumps in Staphylococcus aureusJournal of Antimicrobial Chemotherapy, 2002
- Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4The Journal of Pharmacology and Experimental Therapeutics, 2002
- Mutant Prevention Concentration as a Measure of Fluoroquinolone Potency against MycobacteriaAntimicrobial Agents and Chemotherapy, 2000
- Intracellular targets of moxifloxacin: a comparison with other fluoroquinolonesJournal of Antimicrobial Chemotherapy, 2000
- Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementationNutrition Research, 1999
- Inducible NorA-mediated multidrug resistance in Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1995
- In Vitro Activity of Fluoroquinolones against Gram-Positive BacteriaDrugs, 1995
- Efflux-mediated fluoroquinolone resistance in Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1993
- Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugsJournal of Ethnopharmacology, 1981