Opiate receptor modifications in the rat brain after chronic treatment with haloperidol and suipiride
- 1 January 1990
- journal article
- Published by SAGE Publications in Journal of Psychopharmacology
- Vol. 4 (1) , 7-12
- https://doi.org/10.1177/026988119000400102
Abstract
Anatomical, electrophysiological and pharmacological data support the existence of a pronounced interaction between dopamine (DA) and opioids. In particular, chronic administration of DA antagonist drugs modifies opiate peptides and opiate receptors. In this paper we focused, by means of quantitative receptor autoradiography, on the modifications induced by chronic neuroleptic treatment, in patches versus diffuse distribution, of opiate receptors in the striatum, and we also studied the different effects of haloperidol and sulpiride on striatal and cortical receptors. We found a significant decrease of the number of (3H)- naloxone binding sites in the striatal patches of treated animals but no effects in the matrix. We also observed, in haloperidol-treated animals, an increase of (3H)-naloxone binding sites in the medial cortex, and in sulpiride-treated animals an increase in the lateral and dorsal cortex. Two main observations arise from our data: (a) a differential effect is produced by neuroleptic treatment on opiate receptors in patches and in matrix; (b) an opposite influence is exerted by sulpiride and haloperidol on opiate receptors in the cortex and in striatum.Keywords
This publication has 23 references indexed in Scilit:
- Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrixNeuroscience, 1987
- Visualization of multiple opioid-receptor types in rat striatum after specific mesencephalic lesions.Proceedings of the National Academy of Sciences, 1987
- Evolving concepts on the interactions between antidepressant treatments and monoamine neurotransmittersNeuropharmacology, 1987
- Correspondence between the Dopamine islands and striosomes of the mammalian striatumNeuroscience, 1984
- Electron microscopic autoradiographic localization of opioid receptors in rat neostriatumNature, 1984
- Effects of naloxone on methamphetamine and apomorphine stereotypy and on haloperidol catalepsy in ratsPsychopharmacology, 1984
- An immunohistochemical study of enkephalins and other neuropeptides in the striatum of the cat with evidence that the opiate peptides are arranged to form mosaic patterns in register with the striosomal compartments visible by acetylcholinesterase stainingNeuroscience, 1981
- Modulation of opiate receptor binding in striatum and amygdala by selective mesencephalic lesionsBrain Research, 1980
- Clumping of acetylcholinesterase activity in the developing striatum of the human fetus and young infantProceedings of the National Academy of Sciences, 1980
- Excitation-mediating and inhibition-mediating dopamine-receptors: A new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical dataPsychopharmacology, 1976