Evaluation of tumor oxygenation by color duplex sonography: A new approach

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Abstract
Description of a new noninvasive method for the evaluation of tissue oxygenation in head and neck cancer. Prospective nonrandomized controlled study in an academic medical center on 20 patients with neck metastases of head and neck cancer. Metastases were investigated using color duplex sonography and pO2 histography. The vascularization in sonography was quantitatively evaluated by color pixel density and compared to the pO2 values of the same nodes. The correlation between vascularization and flow velocity was 0.71. For the mean/median pO2 -values and for the pO2 readings <10.0 mmHg correlations were r = 0.65 / 0.76 and 0.71. This sonographic method allows a safe and reliable evaluation of oxygenation in metastases of head and neck cancer. The new approach is an alternative to pO2 histography and may play a future role in the planning of radiotherapy in the neck.