Ionic determinants of bioelectrical spiking activity in the pancreatic B-cell
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 395 (3) , 201-203
- https://doi.org/10.1007/bf00584810
Abstract
A rise in extracellular glucose concentration from 8.3 to 16.7 mM stimulates both Ca2+ inflow and K+ exit in perfused rat pancreatic islets. These ionic changes are associated with an increase in bioelectrical spiking activity. From a quantitative analysis of45Ca and86Rb outflow from prelabelled islets, it is proposed that each electrical spike coincides, approximately, with the entry of 0.8 fmol of Ca2+ and exit of 3.6 fmol of K+ per mm2 of cell surface.Keywords
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