Generation of Stable Synthetic Equivalents of Unstable α-Alkoxyacetaldehydes: An Improved Preparation of Dirithromycin
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (11) , 1089-1091
- https://doi.org/10.1055/s-1993-26006
Abstract
Described is the in situ preparation of the hemiacetals of α-alkoxy-acetaldehydes. The hemiacetals are generated by hydrolysis of an acetal precursor in aqueous acetonitrile solutions. These hemiacetals serve as stable aldehyde equivalents, thus circumventing the production and isolation of unstable α-alkoxyaldehydes. The hemiacetal of 2-methoxyethoxyacetaldehyde is utilized in an effective and efficient preparation of Dirithromycin (LY237216).Keywords
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