PARAQUAT TOXICITY AND PULMONARY SUPEROXIDE-DISMUTASE - ENZYMIC DEFICIENCY OF LUNG MICROSOMES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (1) , 155-158
Abstract
Paraquat stimulates the microsomal generation of superoxide radical, O2-, and hydrogen peroxide, H2O2. The detoxification of these 2 oxidants is accomplished by superoxide dismutase (SOD) and catalase, respectively. SOD activity could not be detected in [rat] lung microsomes but was found in microsomes of both kidney and liver. This deficiency may be involved in the pulmonary specificity of paraquat.

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