Na + -Selective Ionophoric Material Derived from Electric Organ and Kidney Membranes
- 1 April 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (4) , 1191-1194
- https://doi.org/10.1073/pnas.70.4.1191
Abstract
Material that increases black lipid-membrane (oxidized cholesterol) conductance has been demonstrated in the acid-soluble fraction of tryptic digests of membrane fractions from Electrophorus electric organ and beef kidney. The conductance change elicited by this material is highly selective for Na + . The activity of the material was greatly enhanced by passage through DEAE-cellulose. Activity could be destroyed by further incubation with Pronase. Since conductivity increases exponentially with dose of ionophore, the conductive unit may be an oligomer.Keywords
This publication has 16 references indexed in Scilit:
- Studies concerning the possible reconstitution of an active cation pump across an artificial membraneThe Journal of Membrane Biology, 1972
- Ion Transport Through Excitability-Inducing Material (EIM) Channels in Lipid Bilayer MembranesThe Journal of general physiology, 1972
- Functions of the E-ATP and E-P complexes in the membrane ATPase reactionBiochimica et Biophysica Acta (BBA) - Biomembranes, 1972
- Purification and characterization of
(Na . I. The influence of detergents on the activity of(Na in preparations from the outer medulla of rabbit kidneyBiochimica et Biophysica Acta (BBA) - Biomembranes, 1971 - Chemical machines, Maxwell's demon and living organismsJournal of Theoretical Biology, 1971
- Affinity of antamanide for sodium ionsFEBS Letters, 1970
- The Nature of the Negative Resistance in Bimolecular Lipid Membranes Containing Excitability-Inducing MaterialThe Journal of general physiology, 1970
- Reconstitution of an ATP-mediated Active Transport System across Black Lipid MembranesNature, 1969
- The Discovery, Isolation, Elucidation of Structure, and Synthesis of AntamanideAngewandte Chemie International Edition in English, 1968
- THE ROLE OF SODIUM IONS IN THE ACTIVATION OF ELECTROPHORUS ELECTRIC ORGAN ADENOSINE TRIPHOSPHATASEProceedings of the National Academy of Sciences, 1963