Abstract
Modified leukotomies were performed on 5 patients with severe, incapacitating obsessional neurosis. Symptoms had been present for .gtoreq. 6 yr in all patients, and 3 had been ill for > 20 yr. All had received adequate trials of more conventional treatments before the leukotomy but had shown little response. At the time of follow-up, which ranged from as early as 1 yr to as late as nearly 7 yr after surgery, each patient''s condition had improved. One was considered to be in full remission, 3 were much improved, and 1 was still symptomatic but improved.