Influence of Iodide on Cataractogenesis in Emory Mice

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Abstract
Cataract development was studied in two groups of Emory mice by periodical biomicroscopic examinations (beginning at 5 weeks of age) and by a final evaluation of water-soluble SH groups in the lenses. The experimental group was given 256 μg iodide/kg body weight with the drinking water throughout the study. The untreated control group received tap water. Iodide treatment induced a delay of cataract formation, resulting in a significant reduction of the time to progress from cataract degree 1 to degree 2 (iodide-treated group 12.8 ± 1.7 weeks, untreated group 9.9 ± 1.0 weeks; p •OH-scavenging effect of iodide and to the oxidative changes in the lens occurring during progression of cataract development.

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