The in-vitro activity of cefotetan against Serratia spp. And Enterobacter spp. in comparison with other cephalosporins

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Abstract
The in-vitro activity of cefotetan against 161 strains of Enterobacter spp. and 107 strains of Serratia spp. was evaluated in comparison with other cephalosporins; the strains examined were recently collected from several laboratories in different areas. By using a microdilution method in broth the MICs of the following antibiotics were determined: cefotetan, cephalothin, cefoxitin, cefoperazone, cefotaxime, moxalactam and ceftazidime. In addition, the antibiotic resistance of the isolates to three aminoglycosides (gentamicin, tobramycin, amikacin) was evaluated by a disc diffusion method. About half of the strains of Serratia spp. and 15% of Enterobacter spp. were found resistant to gentamicin and broadly the same pattern was recorded for tobramycin; in contrast, 93% of all strains were susceptible to amikacin. More than 90% of Serratia were susceptible to cefotetan, the two aminothiazole cephalosporins and to moxalactam; the other cephalosporins were all distinctly less active. About one-third of Enterobacter strains were resistant to cefotetan and the same was recorded for cefoperazone; the aminothiazoles and the oxa-lactam were more active, although several strains highly resistant to all cephalosporins were frequently encountered. No correlation was found between resistance to aminoglycosides and any particular level of activity of the third-generation cephalosporins. Cefotetan was very active against Serratia but distinctly less so against Enterobacter , whose resistance to all cephalosporins tested was, on the whole, higher than that reported in other studies.

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