Hypoxia at Normal Atmospheric Pressure As a Cause of Congenital Malformations in Mice.
- 1 January 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 94 (1) , 87-88
- https://doi.org/10.3181/00379727-94-22862
Abstract
Exposure of mice for 2 hours on the 10th day of pregnancy to an atmosphere of 6% O2 - 94% N at normal atmospheric pressure (760 mm Hg) resulted in malformed ribs and vertebrae in progeny of the kind found after exposure to equivalent low concentrations of O2 molecules at an atmospheric pressure of 226 mm Hg. Results harmonize with the interpretation previously advanced that the effect of low pressures on the mother and her unborn litter was essentially that of hypoxia.Keywords
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