Combined transport of water and ions through membrane channels
- 1 January 2004
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 385 (10) , 921-6
- https://doi.org/10.1515/bc.2004.120
Abstract
The coupling of ion and water flow through membrane channels is under dispute. Among all human aquaporins only aquaporin-6 exhibits ion channel activity. Whether aquaporin-6 functions also as a water channel cannot yet be determined with confidence. Similarly, a comparison of single-channel water permeabilities from ion channels and aquaporins suggests that ion channels may play a secondary role as water channels. However, the fraction of absorbed fluid that crosses epithelial ion channels still remains to be determined.Keywords
This publication has 42 references indexed in Scilit:
- Molecular Basis of Proton Blockage in AquaporinsStructure, 2004
- Characterization of Aquaporin-6 as a Nitrate Channel in Mammalian CellsJournal of Biological Chemistry, 2002
- Reconstituting the Barrier Properties of a Water-tight Epithelial Membrane by Design of Leaflet-specific LiposomesJournal of Biological Chemistry, 2000
- Functional reconstitution and characterization of AqpZ, the E. coli water channel proteinJournal of Molecular Biology, 1999
- Purification and Functional Reconstitution of Soybean Nodulin 26. An Aquaporin with Water and Glycerol Transport PropertiesBiochemistry, 1998
- Streaming potential measurements in αβγ-rat epithelial Na + channel in planar lipid bilayersProceedings of the National Academy of Sciences, 1997
- Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approachProceedings of the National Academy of Sciences, 1996
- The Grotthuss mechanismChemical Physics Letters, 1995
- A Multifunctional Aqueous Channel Formed by CFTRScience, 1992
- Streaming potential measurements in Ca2+-activated K+ channels from skeletal and smooth muscle. Coupling of ion and water fluxesBiophysical Journal, 1989