Complete nucleotide sequence of a cloned cDNA derived from the major adult -globin mRNA ofX. laevis
Open Access
- 11 March 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (5) , 1537-1542
- https://doi.org/10.1093/nar/11.5.1537
Abstract
The complete sequence of a cloned cDNA derived from the major adult α-globin mRNA of Xenopus laevis (the South African Clawed Toad) is presented. The sequence contains the complete coding and 3′ non-coding regions of the mRNA and part of the 5′ non-coding region. The amino acid sequence of the encoded α-globin polypeptide has been deduced and is compared to other α-globin polypeptides. We find that the sequence is equally diverged from a bullfrog tadpole α-globin polypeptide and human a-globin polypeptide suggesting that these three sequences may have diverged from a common ancestral sequence several hundred million years ago.Keywords
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